![]() ![]() The computational resources required to directly control the muscle activation patterns required for gait are theoretically immense due to the numerous degrees of freedom in gait. ![]() Gait dysfunction compromises self-efficacy and negatively impacts autonomy, community participation, and quality of life 5, 6 motivating further investigation to better understand the interaction between supraspinal lesions, impaired descending commands, altered muscle activity, and resulting gait deficits 7, 8, 9, 10. Gait dysfunction following stroke is widespread, persistent, and well described including decreased gait speed, increased paretic limb swing time, reduced paretic propulsion, and diminished peak ankle power 2, 3, 4. Stroke is the leading cause of physical disability in adults worldwide 1. Significant correlations were revealed between MSA and motor neurophysiological parameters adding evidence to our understanding of MSA as a correlate of neural function and highlighting the utility of combining MSA with other relevant outcomes to aid interpretation of this analysis technique. Conversely, motor neurophysiological parameters, including soleus MEP area, revealed that MEP latency differentiated control and HFH individuals. MSA was able to differentiate control and LFH individuals. Concurrently, transcranial magnetic stimulation (TMS) was administered, during walking, to elicit motor evoked potentials (MEPs) in the plantarflexor muscles during the pre-swing phase of gait. ![]() Surface EMG was collected from twenty-four participants while walking at their self-selected speed. Here we sought to determine the relationship between MSA and accepted neurophysiological parameters of motor efficacy in healthy controls, high (HFH), and low (LFH) functioning stroke survivors. However, controversy remains regarding this interpretation, specifically attribution of MSA as a neuromarker. Muscle Synergy Analysis (MSA), derived from electromyography (EMG), has been argued as a method to quantify the complexity of descending motor commands and serve as a direct correlate of neural function. Stroke survivors often exhibit gait dysfunction which compromises self-efficacy and quality of life. ![]()
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